Cross-reactive potential of human T-lymphocyte responses in HIV-1 infection

Giorgi, Elena E. and Balachandran, Harikrishnan and Muldoon, Mark and Letvin, Norman L. and Haynes, Barton F. and Korber, Bette T. and Santra, Sampa (2014) Cross-reactive potential of human T-lymphocyte responses in HIV-1 infection. Vaccine, 32 (31). pp. 3995-4000. ISSN 0264-410X

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An effective HIV-1 vaccine should elicit sufficient breadth of immune recognition to protect against the genetically diverse forms of the circulating virus. Evaluation of the breadth and magnitude of cellular immune responses to epitope variants is important for HIV-1 vaccine assessment. We compared HIV-1 Gag-specific T-lymphocyte responses in 20 HIV-1-infected individuals representing two different HIV-1 subtypes, B and C. By assessing T lymphocyte responses with peptides based on natural HIV-1 variants, we found evidence for limited cross-reactivity and significantly enhanced within-clade responses among clade B-infected subjects, and not among clade C-infected subjects.

Item Type: Article
Uncontrolled Keywords: HIV-1, vaccine development, T-lymphocytes, immunology
Subjects: MSC 2010, the AMS's Mathematics Subject Classification > 92 Biology and other natural sciences
Depositing User: Dr Mark Muldoon
Date Deposited: 21 Dec 2015
Last Modified: 20 Oct 2017 14:13

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