The Ariel Project: A prospective cohort study of maternal-child transmission of human immunodeficiency virus type 1 in the era of maternal antiretroviral therapy

Van Dyke, R. B. and Korber, B. T. and Popek, E. and Macken, C. and Widmayer, S. M. and Bardeguez, A. and Hanson, I. C. and Wiznia, A. and Luzuriaga, K. and Viscarello, R. R. and Wolinsky, S. and Ariel Core Investigators, the (1999) The Ariel Project: A prospective cohort study of maternal-child transmission of human immunodeficiency virus type 1 in the era of maternal antiretroviral therapy. Journal of Infectious Diseases, 179 (2). pp. 319-328. ISSN 0022-1899

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Abstract

In a prospective cohort study, clinical and biologic factors that contribute to maternal-child transmission of human immunodeficiency virus type 1 (HIV-1) were studied. HIV-infected pregnant women and their infants were evaluated prospectively according to a standardized protocol. Of 204 evaluable women, 81% received zidovudine during their pregnancy. The infection rate among the 209 evaluable infants was 9.1%. By univariate analysis, histologic chorioamnionitis, prolonged rupture of membranes, and a history of genital warts were significantly associated with transmission. Additional factors associated with transmission that approached significance included a higher maternal virus load at delivery and the presence of cocaine in the urine. In a logistic regression model, histologic chorioamnionitis was the only independent predictor of transmission. Despite a significantly higher transmission rate at one site, no unique viral genotype was found at any site. Thus, chorioamnionitis was found to be the major risk factor for transmission among women receiving zidovudine.

Item Type:	Article
Additional Information:	© 1999 by Infectious Diseases Society of America. The Ariel Core Investigators are: Arthur Ammann, Irvin Chen, April Gifford, David Ho, Richard A. Koup, Paul Krogstad, Mark Muldoon, James Mullins, and Bruce Walker.
Subjects:	MSC 2010, the AMS's Mathematics Subject Classification > 92 Biology and other natural sciences
Depositing User:	Dr Mark Muldoon
Date Deposited:	13 Apr 2006
Last Modified:	20 Oct 2017 14:12
URI:	https://eprints.maths.manchester.ac.uk/id/eprint/219

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